Everything about Ethacrynic Acid totally explained
Ethacrynic acid (trade name
Edecrin) is a
loop diuretic medication used to treat
high blood pressure and the
swelling caused by diseases like
congestive heart failure,
liver failure, and
kidney failure. Unlike the other loop diuretics, ethacrynic acid isn't a
sulfonamide and thus, its use isn't contraindicated in those with sulfa allergies.
Ethacrynic acid is a phenoxyacetic acid derivative containing a ketone and a methylene group. A cysteine adduct is formed with the methylene group and this is the active form.
Administration
25 mg and 50 mg tablets are available for oral use. The sodium salt (ethacrynate sodium) can also be given
intravenously.
Side effects
As a
diuretic, ethacrynic acid can cause frequent urination, but this usually resolves after taking the drug for a few weeks.
Ethacrynic acid can also cause
low potassium levels, which may manifest as muscle cramps or weakness. It has also been known to cause reversible or permanent hearing loss and liver damage. On oral administration, it produces diarrhea; intestinal bleeding may occur at higher doses.
Mechanism of action
Acts by inhibiting sodim-potassium-chloride cotransport in the ascending loop of Henle. Loss of potassium ions is less marked but chances of hypochloremic alkalosis are greater. The dose response curve of ethacrynic acid is steeper than that of furosemide and, in general, it's less manageable; dose range is 50-150mg.
Ethacrynic acid and its glutathione-adduct are potent inhibitors of Glutathione S-transferase family members, which are enzymes involved in xenobiotic metabolism.
Further Information
Get more info on 'Ethacrynic Acid'.
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